Medical terminology represents a highly structured lexical subsystem that ensures precision and consistency in professional communication. Within this system, infectious disease terminology occupies a particularly important position due to the global impact of communicable diseases and the rapid development of medical science. The present study investigates the lexicographic features of infectious disease terminology in English and Uzbek languages. The research focuses on the representation, definition, and standardization of medical terms in lexicographic sources such as medical dictionaries and terminological databases. A comparative analysis of selected infectious disease terms was conducted using English and Uzbek medical dictionaries. The findings demonstrate that most infectious disease terms originate from Latin and Greek roots and exhibit a high degree of internationalization. At the same time, Uzbek lexicography reflects the adaptation of these international terms to national linguistic norms while preserving semantic accuracy. The study highlights the role of lexicographic description in the standardization of medical terminology and emphasizes the importance of consistent terminological representation in multilingual medical communication.