When a new phenomenon or an advance in technology originates in society, it is natural that new terms appear to refer to the phenomenon, technology, new use, and so on. The impact of this new disease, COVID-19 is so strong that no one has been able to foresee how long they will have to live under conditions of isolation and social distance. COVID-19 has changed our lives drastically. A new normal is required, and it is affecting various areas of daily life. For this reason, new terms have appeared and certain expressions have acquired greater relevance due to their use in a generalized context due to the pandemic. There are few published studies on the impact of COVID-19 on the Spanish language. This research analyzes this effect of coronavirus pandemic on the lexical inventory of Spanish. Its main objective is to analyze the difference in the use of terms related to the coronavirus, depending on the country or region in the Spanish-speaking world. To collect the data, an online survey was conducted using a semi-closed questionnaire. With the help of volunteers, 346 questionnaires were collected for this study. The attitude of users towards the use of the new terms is examined, as well as the discriminatory use of language around the pandemic. It is concluded that the norm will end up accepting neologisms and variants that Spanish-speakers have innovated and put into circulation in this situation.