The problem of language interference being a process which retards the mastering of a second language, having appeared as a result of transference of speech skills from one contact language into another (from the native language into the foreign language, from the first foreign language into the second one), has concerned researchers for decades. This phenomenon has a direct influence on the success of an individual’s mastery of a foreign language and its use—involving both receptive and productive types of speech activities. Interference resulting from the negative impact of one language on another covers all linguistic levels of the language being studied, including lexical, which leads to deviations from the language norm and numerous lexical errors of students. Linguists and methodologists are trying to find ways to reduce the interference of the language being studied at the lexical level in order to optimize the process of mastering a foreign language and minimize lexical errors of students. The purpose of the current study is to investigate ways to overcome intra-language and inter-language lexical interference in junior courses of the Azerbaijan University of Languages and to verify the validity of these methods in the course of a practical experiment.