Two experiments examined the feasibility of psychological assessment using interactive voice response (IVR) technology and the potential sensitivity of such assessments to alcohol and fatigue effects. In Experiment 1, 10 subjects performed a 12-min battery of six IVR-administered tasks, Monday through Friday, over 2 weeks. Minimal learning effects were evident during training. Repeated administrations indicated high test-retest reliabilities. In Experiment 2 (double-blind, alcohol/placebo crossover design), 7 subjects were tested every 2 h over a 24-h period during two experimental sessions (peak blood alcohol concentrations =80 mg/dL). Several IVR-administered tasks were sensitive to alcohol impairment, but not as sensitive as laboratory-based measures specifically designed to assess alcohol impairment. Little evidence for fatigue-related impairment was obtained. The results support optimism for the potential to assess psychomotor and cognitive functioning distally via telephony; however, further refinement and validation of the methods are needed.