This dataset contains multimodal neuroimaging and physiological data from a study investigating the effects of Targeted Memory Reactivation (TMR) during REM sleep on emotional reactivity. Participants encoded affective images paired with sounds, received auditory cues during subsequent REM sleep, and were rescanned 48 hours later during arousal rating tasks in an fMRI scanner. The dataset includes structural and functional MRI, polysomnographic recordings with EEG during sleep, heart rate measurements, and behavioral ratings across three sessions spanning two weeks.