Both odor and temperature have been suggested to shape occupants’ perception of indoor environment, yet quantitative evidence regarding their interdependence remains limited. This study investigated their cross-modal effects on human responses in office environments, theoretically based on negativity bias, revenge effect, and One-Vote-Veto effect. A single-blind 2 × 2 within-subject experiment was conducted in the Aachen Workplace Simulation Lab. 23 healthy, mostly young participants experienced room atmospheres with pleasant (0.7 ppm pentyl acetate) and unpleasant (5 ppm 1-butanol) odors at neutral (24°C) and slightly warm (28.5°C) temperatures. Standardized questionnaires assessed subjective satisfaction and sensation across sensory domains before and after olfactory adaptation. Modern statistical advancements—including causal inference, adjustment criterion, and Bayesian region of practical equivalence—were leveraged to address existing methodological limitations in multi-domain research. Results revealed cross-modal main effects, with increased warmth reducing olfactory satisfaction. Marginal temperature x odor interactions were found for thermal and overall satisfaction, while other cross-modal effects remained inconclusive. Substantial inter-individual variability was observed in odor valence ratings. These findings highlight the interdependence of thermal and olfactory perception and partially support the notion that negative experiences from one domain can influence another; however, One-Vote-Veto effects were not confirmed. The study underscores the need for holistic indoor environmental quality assessments and follow-up multi-domain research. Methodologically, it showcases application of modern statistical tools to improve transparency and rigor in causal human-centric building science. Challenges related to odor selection and concentration manipulation are highlighted as key areas for improvement in related future research.