This preprint presents a systematic, research-oriented practicum that guides the reader through the entire modern NLP pipeline: from tokenisation and vectorisation to fine-tuning of large language models, retrieval-augmented generation, and reinforcement learning from human feedback. A distinctive feature of the work is its consistent attention to low-resource and morphologically rich languages -- original contributions on Tajik and Tatar, including subword tokenisers, word embeddings, lexical databases, and transliteration benchmarks, are woven throughout the twelve sessions, demonstrating how modern NLP can be adapted to data-scarce environments without sacrificing rigour. Each session combines concise theory with detailed implementation plans, formalised evaluation metrics, and transparent assessment criteria. The work is not a conventional textbook: it is designed as a reproducible research artefact where every session requires publishing code, models, and reports in public repositories. All experiments are conducted on a single evolving corpus, and the work advocates open-weight models over commercial APIs, with special attention to the Hugging Face ecosystem. Designed for senior undergraduates, graduate students, and practising developers seeking to implement, compare, and deploy methods from classical ML to state-of-the-art LLM-based systems.