Background. The article presents an analysis of immunological markers — the level of natural antibodies to regulators of the main biochemical systems, including the inhibitory and excitation systems, opiate and anti-opiate, biogenic amines, renin-angiotensin, anti-bodies to hemostasis proteins in the blood plasma of people with phantom limb pain that developed after limb amputation, due to combat surgical trauma. It has been established that immunological indicators characterizing the main systems of regulation of human homeostasis in these patients significantly exceed the normal level. The correlation of the antibody level did not depend on the self-assessment of the phantom pain severity degree according to the chi-word rating scale. Purpose. To study the level of immunological markers — the level of natural antibodies to regulators of the main biochemical systems, including inhibition and excitation, opiate and anti-opiate, biogenic amines, renin-angiotensin, homeostasis proteins in the blood serum of individuals suffering from phantom pain syndrome in order to objectify the pain status. Materials and methods. Clinical studies were conducted on the basis of the Branch No. 2 of the National Medical Research Center for Military Medical Technology named after A. A. Vishnevsky of the Ministry of Defense of the Russian Federation. Results. Monitoring the individual profile of natural antibody level to endogenous regulators optimizes the personalization of the patient's treatment and rehabilitation program, as it provides the possibility of biochemically assess of the inhibition and excitation system indicators, the level of tolerance of pain thresholds, and the state of psycho-emotional status. Conclusion. The immunological indicators obtained as a result of the research, characterizing important biochemical human regulatory systems, exceeded the normal level, which indicates a tense, activated functional state of the body.