Abstract Introduction Depression and anxiety have been associated with emotional memory biases, disturbed sleep, and cognitive deficits. The goal of the present study is to investigate the effects of elevated levels of depressive and anxiety symptoms on sleep physiology and sleep-dependent consolidation of emotional memory and reactivity over a mid-day nap in young college students. Methods Data collection is ongoing, preliminary analyses are based on 34 participants (26F, 7M, 1 non-binary, 18-27 yrs). Based on well-validated depression and anxiety scales, participants were classified into high (n=10) vs low (n=24) symptom groups. Participants studied negative and neutral picture stimuli and rated them on the dimensions of valence and arousal. Recognition memory was tested after a 5 hr interval which included a high-density EEG monitored 90 min nap. Results We do not observe any group differences in memory accuracy (d’) or in selectivity for emotional stimuli. In the entire sample, depressive symptoms correlate with decision criterion (C) for negative stimuli (r = -0.357, p=.04), such that individuals with higher depressive symptoms have a more liberal responding bias for negative stimuli. Napping is associated with a decrease in arousal ratings across all participants (F(1,32)=5.43, p=.03), and the high mood symptom group rate stimuli as more arousing (F(1,32)=13.96, p<.001). Further, high levels of trait anxiety is associated with more negative valence ratings post-nap (r = -0.350, p=.03). Conclusion The effects of a mid-day nap on memory consolidation and reactivity for emotional stimuli are similar between individuals with high vs low levels of mood symptoms, but heightened levels of depression and anxiety are associated with altered response bias and higher emotional reactivity. Future plans involve comparisons of NREM oscillations between groups and investigation of their relations with task performance. Support (if any) Iowa Neuroscience Institute “2021 Ideas Lab” Award (Baran)