Abstract This paper presents the introduction of frame semantics in SciE-Lex, a lexical database of biomedical English, in order to establish frame-based semantic networks among the lexical units contained in the database and draw attention to the domain-specific meanings and syntactic patterns that they exhibit. Taking the general English FrameNet database as a reference and the verbs diminish, compete, and perturb as an illustration, this paper shows how modelling the syntacticosemantic properties of biomedical English results in three scenarios: (a) the general English FrameNet analysis is fully adequate for biomedical usage (b) the frame elements in the general English FrameNet do not fully characterize the semantic and syntactic properties of the lexical items in biomedical English, so an existing frame needs to be customized (c) the frame(s) evoked in general English are different, so either the customization of an existing frame or the addition of a new frame is necessary.