Mindful meditation, an exercise which encourages its practitioners to be present in the moment and to be aware of their current emotions, thoughts, and sensations, has been shown to affect the processing of emotional information (Sobolewski et al., 2011) and to increase empathy (Tan, Lo, & Macrae, 2014). The prefrontal cortex has been implicated in these processes (Seitz, Nickel, & Azari, 2006). We sought to investigate the neural mechanisms which underlie how mindful meditation affects emotional processing and to determine whether any changes in brain activity could be linked to changes in empathy. Participants in our experimental group practiced mindful meditation for ten minutes. Those in the control groups either listened to an unexciting newscast or sat quietly for ten minutes. Next, participants in all conditions viewed a series of emotionally valenced images from the International Affective Picture System (IAPS) (Lang, Bradley, & Cuthbert, 2008). As they viewed the images, activity in the prefrontal cortex was monitored with functional near-infrared spectroscopy (fNIRS). Following the presentation of the IAPS images, participants completed questionnaires and inventories that measured empathy, previous experience with meditation, and personality traits. As well as differences in empathy between participants who meditated and participants who did not, we expect to discover any variations in patterns of prefrontal cortical activity during the viewing of positive, negative, and neutral imagery. We hope that our results will elucidate how mindful meditation affects emotional processing and the development of empathy, and to determine whether certain personality traits, social conservatism, or lack of sleep may predict neural and behavioral responses to mindful meditation. Lang, P.J., Bradley, M.M., & Cuthbert, B.N. (2008). International affective picture System (IAPS): Affective ratings of pictures and instruction manual. Technical Report A-8. University of Florida, Gainesville, FL. Seitz, R.J., Nickel, J., & Azari, N.P. (2006). Functional modularity of the medial prefrontal cortex: Involvement in human empathy. Neuropsychology, 20(6), 743-751. Sobolewski, A., Holt, E., Kublik, E., & Wróbel, A. (2011). Impact of meditation on emotional processing—A visual ERP study. Neuroscience Research, 71(1), 44–48. doi: 10.1016/j.neures.2011.06.002 Tan, L.B.G., Lo, B.C.Y., & Macrae, C.N. (2014). Brief Mindfulness Meditation Improves Mental State Attribution and Empathizing. PLoS ONE, 9(10). doi: 10.1371/journal.pone.0110510