We investigate the relationship between the notion of nuclearity as proposed in Rhetorical Structure Theory (RST) and the signalling of coherence relations. RST relations are categorized as either mononuclear (comprising a nucleus and a satellite span) or multinuclear (comprising two or more nuclei spans). We examine how mononuclear relations (e.g., Antithesis, Condition) and multinuclear relations (e.g., Contrast, List) are indicated by relational signals, more particularly by discourse markers (e.g., because, however, if, therefore). We conduct a corpus study, examining the distribution of either type of relations in the RST Discourse Treebank (Carlson et al., 2002) and the distribution of discourse markers for those relations in the RST Signalling Corpus (Das et al., 2015). Our results show that discourse markers are used more often to signal multinuclear relations than mononuclear relations. The findings also suggest a complex relationship between the relation types and syntactic categories of discourse markers (subordinating and coordinating conjunctions).