The purpose of this study was to evaluate the relationship between emotional responses to sounds, hearing acuity, and isolation, specifically objective isolation (social disconnectedness) and subjective isolation (loneliness). It was predicted that ratings of valence in response to pleasant and unpleasant stimuli would influence the relationship between hearing loss and isolation. Participants included 83 adults, without depression, who were categorized into three groups (young with normal hearing, older with normal hearing, and adults with mild-to-moderately severe hearing loss). Participants made ratings of valence in response to pleasant and unpleasant nonspeech sounds, presented at a moderate overall level in the laboratory. Participants also completed questionnaires related to social disconnectedness and loneliness. Data were analyzed using multiple regression with questionnaire scores as dependent variables. Independent variables were age, gender, degree of hearing loss, perceived hearing handicap, number of depressive symptoms, mean valence rating in response to unpleasant sounds, and mean valence rating in response to pleasant sounds. Emotional responses to pleasant sounds explained significant variability in scores of both social disconnectedness and loneliness. Depressive symptoms also explained variability in loneliness scores. Hearing loss was not significantly related to social disconnectedness or loneliness, although it was the only variable significantly related to ratings of valence in response to pleasant sounds. Emotional responses to pleasant sounds are related to disconnectedness and loneliness. Although not related to isolation in this study, hearing loss was related to emotional responses. Thus, emotional responses should be considered in future models of isolation and hearing loss.