Laboratory work in biology teaching is an effective method to achieve learning objectives. In this practical activity presents about the role of plants, especially papaya fruit as an additional ingredient in the making of papaya bingka. This research aimed to know the students' response to laboratory work of making papaya bingka on sub chapter the role of plants in economics. Measurement of student's response to laboratory work of making papaya bingka using descriptive research. Data collection methods used responses questionnaire along with affective and psychomotor assessments with observation sheet, while cognitive assessments used student worksheet. Responses questionnaire used consisted of positive and negative statements of 12 statemets. The results of student's response showed that the average percentage of students' responses to laboratory work of making papaya bingka on submateri the role of plants in economic was 87% and categorized very high. The results was supported by affective rating of 87.16, psychomotor rating of 87.39 and cognitive rating of 88.70 values.