In this paper, an effective machine translation system from Thai to Khmer language on a website is proposed. To create a web application for a high performance Thai-Khmer machine translation (ThKh-MT), the principles and methods of translation involve with lexical base. Word reordering is applied by considering the previous word, the next word and subject-verb agreement. The word adjustment is also required to attain acceptable outputs. Additional steps related to structure patterns are added in a combination with the classical methods to deal with translation issues. PHP is implemented to build the application with MySQL as a tool to create lexical databases. For testing, 5,100 phrases and sentences are selected to evaluate the system. The result shows 89.25 percent of accuracy and 0.84 for F-Measure which infers to a higher efficiency than that of Google and other systems.