INTRODUCTION: Attractive people elicit more positive first impressions.1 Conversely, facial deformity diminishes quality of life even after surgical reconstruction of a cleft deformity.2,3 Symmetry has been shown to be one significant factor influencing aesthetic judgments of the face.4,5 PURPOSE: To investigate the impact of cleft laterality and attractiveness on the early visual processing of faces with cleft lip. Primary aim: to study the visual markers leading to differential perception of patients with cleft lip. Secondary aim: to evaluate the influence of observer personal history of facial deformity on visual processing of the cleft-affected face. By delineating the focus of visual impression formation, surgeons and their patients may pinpoint the most salient facial features so as to better direct prioritization of surgical reconstruction. MATERIALS AND METHODS: 59 experimental and 59 control facial images were obtained from the senior author’s practice. Experimental images included 15 individuals with repaired cleft lip (6R, 5B, 4L) and 45 with a variety of other facial diagnoses. 240 subjects rated the images for attractiveness. Twenty standardized lookzone regions were mapped onto each facial image. A separate group of 170 subjects observed the images while an infrared eye-tracking camera continuously recorded their eye movements. Personal history of observer facial deformity was solicited. Factorial ANOVA analysis was performed to determine significance of gaze patterns and attractiveness between groups. Outcomes Measured: Image attractiveness was rated on a 1–7 Likert scale. Total number of eye fixations within different lookzone regions was recorded. RESULTS: The following observations were statistically significant at p<0.01 level: (i) Subjects preferentially fixated on the periorbital regions of all faces, but paid greater attention to the perioral region of cleft-affected versus control faces. (ii) Above phenomenon tracked closely to laterality of cleft. (iii) Subjects fixated more on unilateral than on bilateral cleft lip. (iv) More attractive the overall cleft image rating, the less time the perioral region was fixated upon. (v) Observers with personal history of facial deformity fixated longer on the perioral region of cleft faces. CONCLUSION: Observers are drawn to the abnormal region of cleft faces. Unilateral clefts - and cleft faces that are considered less attractive overall - induce relatively greater fixation within the perioral region. Personal history of facial deformity may heighten detection of, and/or diversion towards, the cleft deformity. DISCLOSURE/FINANCIAL SUPPORT:No financial support. None of the authors have any financial interest in any of the products, devices, or drugs mentioned in this manuscript. REFERENCES: 1. Kaplan, RM Is Beauty Talent? Sex Interaction in the Attractiveness Halo Effect 4(2):195–204, Apr 1978 2. Berger Z, Dalton L. Coping with a cleft: Psychosocial adjustment of adolescents with a cleft lip and palate and their parents. Cleft Palate Craniofacial J. 48:435–443 Dec 2009 3. Klassen AF, Stotland MA, Skarsgard ED, Pusic AL. Clinical research in pediatric plastic surgery and systematic review of quality-of-life questionnaires. Clin Plast Surg. (35):251–267 Apr 2008 4. Jones BC, Little AC, Tiddeman BP, Burt DM, Perrett, DI Facial symmetry and judgements of apparent health. Support for a “‘ good genes ‘” explanation of the attractiveness – symmetry relationship, Evol Hum Behav 22(6):417–429 Nov 2001 5. Fink B, Neave N, Manning JT, Grammer K Facial symmetry and judgements of attractiveness, health and personality. Pers Individ Differ 41(3), 491–499 Aug 2006