OBJECTIVE: Examine the production of abstract and concrete nouns in patients with neurodegenerative disease using the Cookie Theft picture description. BACKGROUND: In a previous study, we observed a double dissociation in abstract and concrete word knowledge between the semantic variant of primary progressive aphasia (svPPA) and the behavioral variant of frontotemporal dementia (bvFTD). Compared to age-matched healthy controls, bvFTD patients were significantly more impaired for abstract nouns than for concrete nouns, and their poor abstract knowledge related to atrophy in the inferior frontal gyrus. In contrast, svPPA patients were significantly more impaired for concrete nouns compared to abstract nouns, associated with atrophy to the left temporal lobe. In this study, we test if the same neural regions that are critical for effective abstract and concrete word comprehension also play a role in the production of abstract and concrete words. DESIGN/METHODS: We assess the production of abstract and concrete nouns in 42 bvFTD and 21 svPPA patients using an oral description of the Cookie Theft picture. Patients met published diagnostic criteria, and concreteness or abstractness of each word was calculated using Brysbaert concreteness ratings (Brysbaert, Warriner & Kuperman, 2014). RESULTS: We observe the same double dissociation pattern during production as we previously saw with comprehension: bvFTD patients produce a smaller proportion of abstract nouns than svPPA patients. Moreover, the average concreteness rating for all nouns produced by svPPA patients is lower than for bvFTD. Regression analyses demonstrated that decreased abstract noun production in bvFTD relates to atrophy in the left inferior frontal gyrus. In addition, decreased concrete noun production in svPPA relates to atrophy in the left inferior temporal lobe. CONCLUSIONS: These results corroborate the finding that abstract and concrete nouns are represented in partially dissociable anatomic regions.