State-of-the-art prosody modelling in content-to-speech (CTS) applications still uses the same methodology to predict intonation cues as text-to-speech (TTS) applications, namely the analysis of the generated surface sentences with respect to part of speech, syntactic dependency relations and word order. On the other side, several theoretical studies argue that morphology, syntax, and information (or communicative) structure that organizes a given content (semantic or deep-syntactic structure) with respect to the intention of the speaker show a strong correlation with intonation. However, little empirical work based on sufficiently large corpora has been carried out so far to buttress this argumentation. We present empirical evidence for the Information Structure-Prosody correlation using the Wall Street Journal Penn Treebank corpus recorded by native American English speakers. Our experiments reach a prosody prediction accuracy of 80% using the hierarchical information structure from the Meaning-Text Theory, compared to 59% of the baseline.