Domain adaptation is an important task in order for NLP systems to work well in real applications. There has been extensive research on this topic. In this paper, we address two issues that are related to domain adaptation. The first question is how much genre variation will affect NLP systems ’ performance. We investigate the effect of genre variation on the performance of three NLP tools, namely, word segmenter, POS tagger, and parser. We choose the Chinese Penn Treebank (CTB) as our corpus. The second question is how one can estimate NLP systems ’ performance when gold standard on the test data does not exist. To answer the question, we extend the parsing prediction model in (Ravi et al., 2008) to provide prediction for word segmentation and POS tagging as well. Our experiments show that the predicted scores are close to the real scores when tested on the CTB data.