The paper presents an integral framework for multilingual lexical databases (henceforth MLLD) based on Compreno technology. It differs from the existing approaches to MLLD in the following aspects: 1) it is based on a universal semantic hierarchy (SH) of thesaurus type filled with language-specific lexicon; 2) the position in the SH generally determines semantic and syntactic model of a word; 3) this model proposes a suite of elaborate tools to determine universal and language-specific semantic and syntactic properties and deals efficiently with problems of cross-lingual lexical, semantic and syntactic asymmetry. Currently, it includes English, Russian, German, French and Chinese and proves to be a compatible MLLD for typologically different languages that can be used as a comprehensive lexical-semantic database for various NLP applications.