Chemical sensitivity (CS) is common in the adult population and implies negative effects (e.g. physical symptoms, negative affects and behavioral disruptions) of odorous chemical substances. In Study 1, relations between self-reported CS, negative affect and neuroticism were investigated among Swedish university students (n = 103). CS and neuroticism were positively correlated, suggesting that highly neurotic persons, compared to low- neurotic persons, more easily respond negatively to environmental odors. In Study 2 (n = 40), relations between CS, self-reported noise sensitivity, physical symptoms and odor perception (pleasantness, intensity and familiarity) were examined in a sub-sample of high (HCS) and low (LCS) chemical sensitivity. The HCS group reported higher odor intensity and noise sensitivity. No differences were found in odor pleasantness and familiarity ratings, and in physical symptoms. Overall, the results suggest that normal variation in CS has a general, sensory-unspecific basis.