The article considers indices as elements of the constructing the artistic space of Vikenty Veresaev's novel “The Sisters”. The novel's artistic details are examined within the context of Peirce's Theory of Signs. The article reveals the fundamental concept of the index, outlines the difficulties asso-ciated with defining indices within the text, and examines their role in the construction of the artistic space of the novel. Unlike iconic signs, indexes only point to an object of reality without naming it di-rectly. The characteristics of indices are cognitive-emotive, as they compel individuals to draw upon their empirical experience and cultural knowledge. The author of the article relies on the semiotic na-ture of the intra-textual elements of an artwork. In turn, the text is considered as one of the forms of cultural existence according to the theory of Juri Lotman. The author’s primary focus is on the evolu-tion of the cultural-linguistic paradigm, which has resulted in a significant shift in the interpretation of cultural phenomena. Such alterations are attributable to both synchronic and diachronic processes. Nevertheless, changes become visible due to the existence of a language norm, according to which the cultural code of the nation is built. In conclusion, the author suggests that culture should be defined as the historical memory of the nation. In order to gain an understanding of the cultural context depicted in the novel, it is necessary to possess a certain degree of background knowledge. It becomes possible to dive into artistic mini-worlds with the help of linguistic tools such as linguocultural details. The arti-cle attempts to interpret the fragments that are crucial for comprehending the cultural epoch of the work, based on the material presented in Vikenty Veresaev's novel, 'The Sisters'. It identifies indices, provides lexical-semantic and semantic-pragmatic characterization of lexical units.