This article examines the linguistic, cultural, and pragmatic features of euphemisms in English and Uzbek discourse. Euphemisms—lexical units used to soften or obscure potentially offensive, taboo, or socially sensitive concepts—play a significant role in interpersonal communication and cultural norms. The study provides a comparative analysis of the semantic domains in which euphemisms most frequently occur, including death, illness, bodily functions, age, appearance, and socio-political issues. It also highlights the structural and pragmatic mechanisms of euphemism formation such as metaphor, metonymy, generalization, borrowing, and periphrasis. The findings indicate that while both languages employ euphemisms to maintain politeness and preserve social harmony, English tends toward institutionalized formulaic expressions, whereas Uzbek euphemisms are more culturally loaded and value-oriented. The article concludes that euphemisms reflect national mentality, linguistic worldview, and social etiquette norms.